Hsp90b1^tm1.2Alee
Targeted Allele Detail

Summary

• Symbol: Hsp90b1^tm1.2Alee
• Name: heat shock protein 90, beta (Grp94), member 1; targeted mutation 1.2, Amy Lee
• MGI ID: MGI:4460991
• Synonyms: Grp94^-
• Gene: Hsp90b1 Location: Chr10:86526705-86541308 bp, - strand Genetic Position: Chr10, 43.05 cM
• Alliance: Hsp90b1^tm1.2Alee page

Embryonic lethality in Hsp90b1^tm1.2Alee/Hsp90b1^tm1.2Alee embryos

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:160900
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A floxed and FRT flanked neomycin cassette was inserted in intron 1 and a third loxP site was inserted in intron 2. The neomycin cassette and exon 2 were subsequently removed by cre recombinase. (J:160900)

Generation of the Hsp90b1^tm1.1Alee and Hsp90b1^tm1.2Alee alleles

Expression

In Mice Carrying this Mutation:	24 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hsp90b1 Mutation: 35 strains or lines available

References

• Original: J:160900 Mao C, et al., Targeted mutation of the mouse Grp94 gene disrupts development and perturbs endoplasmic reticulum stress signaling. PLoS One. 2010;5(5):e10852
• All: 1 reference(s)