Pign^m1Nisw
Chemically induced Allele Detail

Summary

• Symbol: Pign^m1Nisw
• Name: phosphatidylinositol glycan anchor biosynthesis, class N; mutation 1, Lee Niswander
• MGI ID: MGI:4460999
• Synonyms: gnz, Gonzo, Pigm^gnz
• Gene: Pign Location: Chr1:105446147-105591402 bp, - strand Genetic Position: Chr1, 49.63 cM, cytoband D
• Alliance: Pign^m1Nisw page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: This mutation is a T to A transversion in the splice donor site of intron 23 (at position 4): GTATCCTT to GTAACCTT. (J:187360)
• Inheritance: Recessive

Disease models

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pign Mutation: 68 strains or lines available

References

• Original: J:187360 McKean DM, et al., Defects in GPI biosynthesis perturb Cripto signaling during forebrain development in two new mouse models of holoprosencephaly. Biol Open. 2012;1(9):874-883
• All: 2 reference(s)