Sh2d3c^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Sh2d3c^tm1Lex
• Name: SH2 domain containing 3C; targeted mutation 1, Lexicon Genetics
• MGI ID: MGI:4461024
• Gene: Sh2d3c Location: Chr2:32611072-32645008 bp, + strand Genetic Position: Chr2, 22.09 cM, cytoband B
• Alliance: Sh2d3c^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:161448
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 4-6 were replaced with a LacZ Neo cassette. Absence of protein was confirmed by Western Blot of spleen lysates. (J:161448)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Sh2d3c Mutation: 30 strains or lines available

Notes

See also, data as provided by Lexicon Genetics, Inc.

References

• Original: J:161448 Al-Shami A, et al., The adaptor protein Sh2d3c is critical for marginal zone B cell development and function. J Immunol. 2010 Jul 1;185(1):327-34
• All: 1 reference(s)