Olig2^{tm1.1(cre)Wdr}
Targeted Allele Detail

Summary

• Symbol: Olig2^{tm1.1(cre)Wdr}
• Name: oligodendrocyte transcription factor 2; targeted mutation 1.1, William D Richardson
• MGI ID: MGI:4461156
• Synonyms: Olig2-cre, Olig2-iCre
• Gene: Olig2 Location: Chr16:91022345-91025565 bp, + strand Genetic Position: Chr16, 52.6 cM
• Alliance: Olig2^{tm1.1(cre)Wdr} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:161358
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Olig2^{tm1.1(cre)Wdr} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Olig2 (MGI:1355331)

• Mutation details: An IRES-Cre-lox-PGK-Neo-lox cassette was introduced into the single exon of Olig2 in ES cells. The PGK-Neo was subsequently removed with cre. (J:161358)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Olig2 (mouse) Summary of all recombinase alleles driven by Olig2. Alliance mouse Olig2 gene page

Disease models

Expression

In Mice Carrying this Mutation:

2 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Olig2 Mutation: 46 strains or lines available

References

• Original: J:161358 Zawadzka M, et al., CNS-resident glial progenitor/stem cells produce Schwann cells as well as oligodendrocytes during repair of CNS demyelination. Cell Stem Cell. 2010 Jun 4;6(6):578-90
• All: 18 reference(s)