Pla2g3^tm1Murm
Targeted Allele Detail

Summary

• Symbol: Pla2g3^tm1Murm
• Name: phospholipase A2, group III; targeted mutation 1, Makoto Murakami
• MGI ID: MGI:4461174
• Gene: Pla2g3 Location: Chr11:3438284-3449350 bp, + strand Genetic Position: Chr11, 2.45 cM
• Alliance: Pla2g3^tm1Murm page

Sperm dysfunction of Pla2g3^tm1Murm/Pla2g3^tm1Murm mice

Show the 5 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:161462
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: The exons (Exon 2-4) encompassing the catalytic domain of the gene were replaced with a neomycin resistance cassette. mRNA expression was undetectable in the heart, kidney and liver from homozygous mutant mice. Immunohistochemical staining of epididymis showed the absence of staining in the spermatozoa, luminal space, and luminal cilia on the epithelium in the caput and corpus of the epididymis. (J:161462)

Generation of the Pla2g3^tm1Murm allele

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pla2g3 Mutation: 18 strains or lines available

References

• Original: J:161462 Sato H, et al., Group III secreted phospholipase A2 regulates epididymal sperm maturation and fertility in mice. J Clin Invest. 2010 May 3;120(5):1400-14
• All: 6 reference(s)