Apc^tm1.1Tyj
Targeted Allele Detail

Summary

• Symbol: Apc^tm1.1Tyj
• Name: APC, WNT signaling pathway regulator; targeted mutation 1.1, Tyler Jacks
• MGI ID: MGI:4461178
• Synonyms: Apc^deltae1-15
• Gene: Apc Location: Chr18:34353977-34455605 bp, + strand Genetic Position: Chr18, 18.53 cM
• Alliance: Apc^tm1.1Tyj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:160399
• Parent Cell Line: V26.2 (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Cre mediated recombination removed exons 1 - 15. This allele is derived from Apc^tm1Tyj. Quantitative RT-PCR confirms the expected 50% reduction in expression in colons from heterozygous mice. (J:160399)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Apc Mutation: 158 strains or lines available

References

• Original: J:160399 Cheung AF, et al., Complete deletion of Apc results in severe polyposis in mice. Oncogene. 2010 Mar 25;29(12):1857-64
• All: 3 reference(s)