Rad51c^tm1.1Bcg
Targeted Allele Detail

Summary

• Symbol: Rad51c^tm1.1Bcg
• Name: RAD51 paralog C; targeted mutation 1.1, Barbara C Godthelp
• MGI ID: MGI:4461202
• Synonyms: Rad51C^*/neo, Rad51C^splice/neo
• Gene: Rad51c Location: Chr11:87267471-87295780 bp, - strand Genetic Position: Chr11, 52.08 cM
• Alliance: Rad51c^tm1.1Bcg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:161642
• Parent Cell Line: IB10/E14IB10 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Intron 5 was replaced with a neo cassette and a modified intron 5 in which a G to A nucleotide substitution 5 nucleotides into intron 5 altered the splice donor site of exon 5. Cre mediated recombination removed the neo cassette. (J:161642)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rad51c Mutation: 24 strains or lines available

References

• Original: J:161642 Smeenk G, et al., Rad51C is essential for embryonic development and haploinsufficiency causes increased DNA damage sensitivity and genomic instability. Mutat Res. 2010 Jul 7;689(1-2):50-58
• All: 1 reference(s)