Mkx^tm1Asah
Targeted Allele Detail

Summary

• Symbol: Mkx^tm1Asah
• Name: mohawk homeobox; targeted mutation 1, Hiroshi Asahara
• MGI ID: MGI:4461226
• Gene: Mkx Location: Chr18:6934966-7004779 bp, - strand Genetic Position: Chr18, 4.53 cM
• Alliance: Mkx^tm1Asah page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:161299
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding region of exon 2 was replaced with a Venus reporter and a floxed neo cassette. The absence of transcript expression was confirmed by RT-PCR on Achilles tendon extracts. (J:161299)

Expression

In Mice Carrying this Mutation:	23 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mkx Mutation: 28 strains or lines available

References

• Original: J:161299 Ito Y, et al., The Mohawk homeobox gene is a critical regulator of tendon differentiation. Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10538-42
• All: 1 reference(s)