Carf^tm1.1Aew
Targeted Allele Detail

Summary

• Symbol: Carf^tm1.1Aew
• Name: calcium response factor; targeted mutation 1.1, Anne West
• MGI ID: MGI:4461230
• Gene: Carf Location: Chr1:60137406-60193112 bp, + strand Genetic Position: Chr1, 30.45 cM
• Alliance: Carf^tm1.1Aew page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:160811
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A FRT-flanked Neo cassette and a single loxP site were placed 5' to exon 8 and a second loxP site was placed at the 3' the end of exon 8. The selection cassette and exon 8 were removed by flp and cre mediated recombination respectively. A shorter mRNA is produced consistent with the deletion of exon 8. (J:160811)

Expression

In Mice Carrying this Mutation:

42 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Carf Mutation: 48 strains or lines available

References

• Original: J:160811 McDowell KA, et al., Reduced cortical BDNF expression and aberrant memory in Carf knock-out mice. J Neurosci. 2010 Jun 2;30(22):7453-65
• All: 3 reference(s)