Dp(10Prmt2-Pdxk)2Yey
Targeted Allele Detail

Summary

• Symbol: Dp(10Prmt2-Pdxk)2Yey
• Name: duplication, Chr 10, Y Eugene Yu 2
• MGI ID: MGI:4461400
• Synonyms: Dp(10)1Yey, Dp(10Prmt2-Pdxk)1Yey, Dp2Yey, Ts2Yey
• Gene: Dp(10Prmt2-Pdxk)2Yey Location: Chr10:76043060-78300782 bp Genetic Position: Chr10, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:161325
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Duplication
• Dp(10Prmt2-Pdxk)2Yey involves 85 genes/genome features (Gm19376, n-R5s77, n-TAagc5 ...) View all
• Mutation details: Cre mediated chromosomal rearrangement between loxP sites in regions proximal to Prmt2 and distal to Pdxk results in duplication of the genes, including Prmt2 and Pdxk, in this approximately 2.3 Mb region that is syntenic with the distal part of human 21q22.3. (J:161325)

Disease models

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Dp(10Prmt2-Pdxk)2Yey Mutation: 3 strains or lines available

References

• Original: J:161325 Yu T, et al., A mouse model of Down syndrome trisomic for all human chromosome 21 syntenic regions. Hum Mol Genet. 2010 Jul 15;19(14):2780-91
• All: 20 reference(s)