Ttll1^tm1Seto
Targeted Allele Detail

Summary

• Symbol: Ttll1^tm1Seto
• Name: tubulin tyrosine ligase-like 1; targeted mutation 1, Mitsutoshi Setou
• MGI ID: MGI:4461777
• Synonyms: 1KO
• Gene: Ttll1 Location: Chr15:83367970-83395094 bp, - strand Genetic Position: Chr15, 39.4 cM
• Alliance: Ttll1^tm1Seto page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:161297
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 through 4 were replaced with a neo cassette. The absence of protein expression was demonstrated by Western blot analysis on trachea and lung extracts. Immunoblot analysis with anti-TTLL1 antibodies also confirmed the absence of protein expression in brain lysates from homozygous mutant mice. (J:161297, J:345300)

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ttll1 Mutation: 39 strains or lines available

References

• Original: J:161297 Ikegami K, et al., Tubulin polyglutamylation is essential for airway ciliary function through the regulation of beating asymmetry. Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10490-5
• All: 6 reference(s)