Fgfr2^m1Sgg
Chemically induced Allele Detail

Summary

• Symbol: Fgfr2^m1Sgg
• Name: fibroblast growth factor receptor 2; mutation 1, S G Gong
• MGI ID: MGI:4461798
• Synonyms: Fgfr2^W290R
• Gene: Fgfr2 Location: Chr7:129764181-129868538 bp, - strand Genetic Position: Chr7, 73.19 cM
• Alliance: Fgfr2^m1Sgg page

Mutation origin

• Strain of Origin: C3H/HeJ

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Nucleotide substitutions
• Mutation details: ENU mutagenesis induced nucleotide substitutions in exon 7 that result in the amino acid substitution of arginine for tryptophan at position 290 (W290R). This mutation is predicted to disrupt FGFR2 IIIb and IIIc isoforms. (J:160674)
• Inheritance: Not Specified

Disease models

Expression

In Mice Carrying this Mutation:	22 assay results
In Structures Affected by this Mutation:	27 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fgfr2 Mutation: 90 strains or lines available

References

• Original: J:160674 Mai S, et al., The missense mutation W290R in Fgfr2 causes developmental defects from aberrant IIIb and IIIc signaling. Dev Dyn. 2010 Jun;239(6):1888-900
• All: 3 reference(s)