Pank1^tm1.1Suja
Targeted Allele Detail

Summary

• Symbol: Pank1^tm1.1Suja
• Name: pantothenate kinase 1; targeted mutation 1.1, Suzanne Jackowski
• MGI ID: MGI:4462018
• Synonyms: Pank1 KO
• Gene: Pank1 Location: Chr19:34784340-34856855 bp, - strand Genetic Position: Chr19, 29.79 cM, cytoband G1-G3
• Alliance: Pank1^tm1.1Suja page

Small size of Pank1^tm1.1Suja/Pank1^tm1.1Suja Pank2^tm1.1Suja/Pank2^tm1.1Suja mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:161798
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: LoxP sites were inserted to the introns flanking Exon 3. Exon 3 was deleted by Cre-mediated recombination. The deletion resulted also in the removal of the TK/NEO cassette. (J:161798)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pank1 Mutation: 41 strains or lines available

References

• Original: J:161798 Leonardi R, et al., Pantothenate kinase 1 is required to support the metabolic transition from the fed to the fasted state. PLoS One. 2010;5(6):e11107
• All: 5 reference(s)