Ncoa3^tm2.2Jxu
Targeted Allele Detail

Summary

• Symbol: Ncoa3^tm2.2Jxu
• Name: nuclear receptor coactivator 3; targeted mutation 2.2, Jianming Xu
• MGI ID: MGI:4462058
• Synonyms: SRC-3^d
• Gene: Ncoa3 Location: Chr2:165834557-165915162 bp, + strand Genetic Position: Chr2, 86.22 cM, cytoband H2-H4
• Alliance: Ncoa3^tm2.2Jxu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:161101
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 11-12 were floxed and a FLP flanked Neo cassette was inserted within intron 17. The selection cassette and exons 11-12 were removed by flp and cre mediated recombination respectively. (J:161101)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ncoa3 Mutation: 233 strains or lines available

References

• Original: J:161101 Liu Z, et al., Generation and validation of a mouse line with a floxed SRC-3/AIB1 allele for conditional knockout. Int J Biol Sci. 2008;4(4):202-7
• All: 1 reference(s)