Setdb1^tm2.1Enl
Targeted Allele Detail

Summary

• Symbol: Setdb1^tm2.1Enl
• Name: SET domain, bifurcated 1; targeted mutation 2.1, En Li
• MGI ID: MGI:4462266
• Synonyms: Setdb1^2lox
• Gene: Setdb1 Location: Chr3:95230836-95264513 bp, - strand Genetic Position: Chr3, 40.74 cM, cytoband F2
• Alliance: Setdb1^tm2.1Enl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:161089
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 16 and a floxed beta-geo cassette was inserted downstream of exon 16. Cre mediated recombination removed the beta-geo cassette leaving exon 16 floxed. (J:161089)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Setdb1 Mutation: 56 strains or lines available

References

• Original: J:161089 Lohmann F, et al., KMT1E mediated H3K9 methylation is required for the maintenance of embryonic stem cells by repressing trophectoderm differentiation. Stem Cells. 2010 Feb;28(2):201-12
• All: 4 reference(s)