Cacna1c^tm1.1Knt
Targeted Allele Detail

Summary

• Symbol: Cacna1c^tm1.1Knt
• Name: calcium channel, voltage-dependent, L type, alpha 1C subunit; targeted mutation 1.1, Jean-Pierre Kinet
• MGI ID: MGI:4462362
• Synonyms: Cav1.2^loxP
• Gene: Cacna1c Location: Chr6:118564201-119173851 bp, - strand Genetic Position: Chr6, 55.86 cM
• Alliance: Cacna1c^tm1.1Knt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:159698
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An frt flanked neo cassette with a 5' loxP site was inserted upstream of exon 14, and a loxP site was inserted downstream of exon 15. Flp mediated recombination removed the neo cassette leaving exons 14 and 15 floxed. (J:159698)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cacna1c Mutation: 144 strains or lines available

References

• Original: J:159698 Jeon D, et al., Observational fear learning involves affective pain system and Cav1.2 Ca2+ channels in ACC. Nat Neurosci. 2010 Apr;13(4):482-8
• All: 2 reference(s)