Ago2^tm2Ghan
Targeted Allele Detail

Summary

• Symbol: Ago2^tm2Ghan
• Name: argonaute RISC catalytic subunit 2; targeted mutation 2, Greggory J Hannon
• MGI ID: MGI:4462370
• Synonyms: Ago2^mc
• Gene: Ago2 Location: Chr15:72967693-73056777 bp, - strand Genetic Position: Chr15, 33.92 cM
• Alliance: Ago2^tm2Ghan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:161968
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• A 5'HPRT mini gene and puro cassette were inserted into the PAZ domain. (J:161968)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ago2 Mutation: 56 strains or lines available

References

• Original: J:161968 Cheloufi S, et al., A dicer-independent miRNA biogenesis pathway that requires Ago catalysis. Nature. 2010 Jun 3;465(7298):584-9
• All: 1 reference(s)