Elovl4^tm2Kzh
Targeted Allele Detail

Summary

• Symbol: Elovl4^tm2Kzh
• Name: ELOVL fatty acid elongase 4; targeted mutation 2, Kang Zhang
• MGI ID: MGI:4462372
• Synonyms: Elovl4^270x
• Gene: Elovl4 Location: Chr9:83660745-83688330 bp, - strand Genetic Position: Chr9, 45.6 cM
• Alliance: Elovl4^tm2Kzh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:161118
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence, Null/knockout)
• Mutation: Insertion
• Mutation details: Tyrosine codon Y270 in exon 6 was mutated to encode a stop codon. A floxed neomycin resistance cassette was inserted following the mutated codon 270. (J:161118)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Elovl4 Mutation: 36 strains or lines available

References

• Original: J:161118 Cameron DJ, et al., Essential role of Elovl4 in very long chain fatty acid synthesis, skin permeability barrier function, and neonatal survival. Int J Biol Sci. 2007;3(2):111-9
• All: 1 reference(s)