Ecel1^tm1Hiki
Targeted Allele Detail

Summary

• Symbol: Ecel1^tm1Hiki
• Name: endothelin converting enzyme-like 1; targeted mutation 1, Hiroshi Kiyama
• MGI ID: MGI:4462383
• Synonyms: DINE^-
• Gene: Ecel1 Location: Chr1:87075377-87084243 bp, - strand Genetic Position: Chr1, 44.06 cM, cytoband C5
• Alliance: Ecel1^tm1Hiki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:160510
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of the zinc-binding motif encoding exon 13, and a neo cassette with a 3' loxP site was inserted downstream of exon 15. The absence of protein expression was confirmed by western blot analysis on spinal cord extracts. (J:160510)

Disease models

Expression

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ecel1 Mutation: 41 strains or lines available

References

• Original: J:160510 Nagata K, et al., Damage-induced neuronal endopeptidase is critical for presynaptic formation of neuromuscular junctions. J Neurosci. 2010 May 19;30(20):6954-62
• All: 4 reference(s)