Chrna1^tm1Klee
Targeted Allele Detail

Summary

• Symbol: Chrna1^tm1Klee
• Name: cholinergic receptor nicotinic alpha 1 subunit; targeted mutation 1, Kuo-Fen Lee
• MGI ID: MGI:4462390
• Synonyms: AChRalpha1^-
• Gene: Chrna1 Location: Chr2:73393625-73410682 bp, - strand Genetic Position: Chr2, 43.76 cM
• Alliance: Chrna1^tm1Klee page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:161300
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with a neo cassette. The absence of protein expression was confirmed by immunohistochemistry on hindlimb muscle. (J:161300)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chrna1 Mutation: 17 strains or lines available

References

• Original: J:161300 An MC, et al., Acetylcholine negatively regulates development of the neuromuscular junction through distinct cellular mechanisms. Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10702-7
• All: 3 reference(s)