Magoh^Mos2
Chemically induced Allele Detail

Summary

• Symbol: Magoh^Mos2
• Name: mago homolog, exon junction complex core component; modifier of Sox10 2
• MGI ID: MGI:4462402
• Gene: Magoh Location: Chr4:107736952-107744621 bp, + strand Genetic Position: Chr4, 50.18 cM
• Alliance: Magoh^Mos2 page

Mutation origin

• Strain of Origin: BALB/cJ

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Intragenic deletion
• Mutation details: This mutation was discovered in an ENU mutagenesis screen for alterations in the neurocristopathy phenotype of mice homozygous for a targeted mutation of Sox10. The molecular change is a single nucleotide deletion 198delG causing a frameshift resulting in a truncated protein. Aberrantly sized transcript by RT-PCR in brain was not observed. This is a null allele. (J:159625)
• Inheritance: Not Specified

Expression

In Mice Carrying this Mutation:	23 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Magoh Mutation: 16 strains or lines available

References

• Original: J:136642 Matera I, et al., A sensitized mutagenesis screen identifies Gli3 as a modifier of Sox10 neurocristopathy. Hum Mol Genet. 2008 Jul 15;17(14):2118-31
• All: 8 reference(s)