Tg(Ttr-Retn)1Laz
Transgene Detail

Summary

• Symbol: Tg(Ttr-Retn)1Laz
• Name: transgene insertion 1, Mitchell A Lazar
• MGI ID: MGI:4462407
• Transgene: Tg(Ttr-Retn)1Laz Location: unknown
• Alliance: Tg(Ttr-Retn)1Laz page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Ttr-Retn)1Laz expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Retn (MGI:1888506)

• Mutation details: This transgene consists of a mouse transthyretin (Ttr) minigene , which includes 3 kb of the Ttr promoter, the first and second exons of the Ttr gene, resistin (Retn) cDNA bearing the biologically active flag epitope at the 3' end and a polyA tail. Overexpression and quantification of Retn in white adipose tissue and liver was verified by northern blot, immunoblot (western) and radioimmunoassay. (J:91890)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

Three founder lines were established; line 1 is a representative line number.

References

• Original: J:91890 Rangwala SM, et al., Abnormal glucose homeostasis due to chronic hyperresistinemia. Diabetes. 2004 Aug;53(8):1937-41
• All: 1 reference(s)