Acd^tm1.1Blas
Targeted Allele Detail

Summary

• Symbol: Acd^tm1.1Blas
• Name: adrenocortical dysplasia; targeted mutation 1.1, Maria A Blasco
• MGI ID: MGI:4462417
• Synonyms: Tpp1^flox
• Gene: Acd Location: Chr8:106424789-106427748 bp, - strand Genetic Position: Chr8, 53.04 cM
• Alliance: Acd^tm1.1Blas page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:160600
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT flanked neo cassette and a loxP site were inserted in exon 1 and a second loxP site was inserted in intron 4. The neomycin selection cassette was excised using Flp recombinase. (J:160600)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Acd Mutation: 22 strains or lines available

References

• Original: J:160600 Tejera AM, et al., TPP1 is required for TERT recruitment, telomere elongation during nuclear reprogramming, and normal skin development in mice. Dev Cell. 2010 May 18;18(5):775-89
• All: 1 reference(s)