Glul^tm3Whla
Targeted Allele Detail

Summary

• Symbol: Glul^tm3Whla
• Name: glutamate-ammonia ligase; targeted mutation 3, Wouter H Lamers
• MGI ID: MGI:4462791
• Synonyms: GS^fl
• Gene: Glul Location: Chr1:153775692-153785469 bp, + strand Genetic Position: Chr1, 65.43 cM, cytoband G2
• Alliance: Glul^tm3Whla page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:162067
• Parent Cell Line: IB10/E14IB10 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: One loxP site was inserted in the 3' end of intron 1. An FRT flanked Pgk-neo-PgkTkselection casette was inserted along with a second loxP site 600 bp downstream from exon 7. The FRT flanked selection cassette was removed by transient transfection using an FLPe expression vector. (J:162067)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Glul Mutation: 36 strains or lines available

References

• Original: J:162067 He Y, et al., Glutamine synthetase deficiency in murine astrocytes results in neonatal death. Glia. 2010 Apr 15;58(6):741-54
• All: 11 reference(s)