Oaz3^tm1Htan
Targeted Allele Detail

Summary

• Symbol: Oaz3^tm1Htan
• Name: ornithine decarboxylase antizyme 3; targeted mutation 1, Hiromitsu Tanaka
• MGI ID: MGI:4462794
• Synonyms: OAZ-t^-
• Gene: Oaz3 Location: Chr3:94340694-94343958 bp, - strand Genetic Position: Chr3, 40.66 cM, cytoband F2
• Alliance: Oaz3^tm1Htan page

Histological analysis and TUNEL staining of testicular sections of Oaz3^tm1Htan/Oaz3⁺ and Oaz3^tm1Htan/Oaz3^tm1Htan testes

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:161751
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1-5 were replaced with neo by homologous recombination. Northern and western blotting on testes lysates confirmed absence of transcripts and protein. This is a null allele. (J:161751)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Oaz3 Mutation: 21 strains or lines available

References

• Original: J:161751 Tokuhiro K, et al., OAZ-t/OAZ3 is essential for rigid connection of sperm tails to heads in mouse. PLoS Genet. 2009 Nov;5(11):e1000712
• All: 1 reference(s)