Ppib^tm1.1Rjb
Targeted Allele Detail

Summary

• Symbol: Ppib^tm1.1Rjb
• Name: peptidylprolyl isomerase B; targeted mutation 1.1, Richard J Bram
• MGI ID: MGI:4462803
• Gene: Ppib Location: Chr9:65967504-65973905 bp, + strand Genetic Position: Chr9, 35.69 cM
• Alliance: Ppib^tm1.1Rjb page

Decreased body size and kyphosis in Ppib^tm1.1Rjb/Ppib^tm1.1Rjb mice

Show the 5 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:161748
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: This allele was created by crossing Ppib^tm1Rjb with mice bearing MMTV-Cre transgene to remove the third exon franked by targeted loxP sites. Complete loss of gene product was confirmed by western blot in thymocytes. This is a null allele. (J:161748)

Generation of the Ppib^tm1Rjb and Ppib^tm1.1Rjb alleles

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ppib Mutation: 18 strains or lines available

References

• Original: J:161748 Choi JW, et al., Severe osteogenesis imperfecta in cyclophilin B-deficient mice. PLoS Genet. 2009 Dec;5(12):e1000750
• All: 3 reference(s)