Gys2^tm1.1Pro
Targeted Allele Detail

Summary

• Symbol: Gys2^tm1.1Pro
• Name: glycogen synthase 2; targeted mutation 1.1, Peter J Roach
• MGI ID: MGI:4462836
• Synonyms: Gys2^(Lox)
• Gene: Gys2 Location: Chr6:142368339-142418835 bp, - strand Genetic Position: Chr6, 74.04 cM
• Alliance: Gys2^tm1.1Pro page

Decreased glycogen liver content in Gys2^tm1.1Pro/Gys2^tm1.1Pro Speer6-ps1^{Tg(Alb-cre)21Mgn}/0 mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:162043
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 5, and a floxed neo cassette was inserted downstream of exon 6. Cre mediated recombination removes the neo cassette leaving exons 5 and 6 floxed. (J:162043)

Generation of the floxed Gys2^tm1.1Pro allele

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gys2 Mutation: 45 strains or lines available

References

• Original: J:162043 Irimia JM, et al., Impaired glucose tolerance and predisposition to the fasted state in liver glycogen synthase knock-out mice. J Biol Chem. 2010 Apr 23;285(17):12851-61
• All: 2 reference(s)