Gt(ROSA)26Sor^{tm1.1(Sall1)Ryn}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1.1(Sall1)Ryn}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1.1, Ryuichi Nishinakamura
• MGI ID: MGI:4462841
• Synonyms: Gt(ROSA)26Sor^{tm1.1(Sall1)Ryni}
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1.1(Sall1)Ryn} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:162052
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1.1(Sall1)Ryn} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Sall1 (MGI:1889585)

• Mutation details: A floxed neo cassette and tpA Stop sequence followed by an HA-tagged Sall1 ORF were inserted into the ROSA26 locus by homologous recombination such that removal of the tpA stop sequence within the floxed neo cassette would allow transcription of the Sall1 gene. The Neo and STOP were removed by cre mediated recombination. (J:162052)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:162052 Jiang Q, et al., Overexpression of Sall1 in vivo leads to reduced body weight without affecting kidney development. J Biochem. 2010 Mar;147(3):445-50
• All: 1 reference(s)