Hoxc10^tm1Emca
Targeted Allele Detail

Summary

• Symbol: Hoxc10^tm1Emca
• Name: homeobox C10; targeted mutation 1, Ellen M Carpenter
• MGI ID: MGI:4462853
• Synonyms: Hoxc10^-
• Gene: Hoxc10 Location: Chr15:102875231-102880328 bp, + strand Genetic Position: Chr15, 58.03 cM
• Alliance: Hoxc10^tm1Emca page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:161095
• Parent Cell Line: CC1.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 157 bp deletion was made in the second exon to remove all three alpha-helices of the homeodomain, and the deleted sequence was replaced with an inframe fusion of LacZ and neo^R into the coding sequence of exon 2. (J:161095)

Expression

In Mice Carrying this Mutation:	35 assay results
In Structures Affected by this Mutation:	10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxc10 Mutation: 17 strains or lines available

References

• Original: J:161095 Hostikka SL, et al., Axial and appendicular skeletal transformations, ligament alterations, and motor neuron loss in Hoxc10 mutants. Int J Biol Sci. 2009;5(5):397-410
• All: 2 reference(s)