Del(10Prmt2-Pdxk)4Yey
Targeted Allele Detail

Summary

• Symbol: Del(10Prmt2-Pdxk)4Yey
• Name: deletion, Chr 10, Y Eugene Yu 4
• MGI ID: MGI:4818358
• Synonyms: Del(10)1Yey, Del(10Prmt2-Pdxk)1Yey, Del4Yey, Del5Yey, Df(10)1Yey, Df(Prmt2-Pdxk)1Yey
• Gene: Del(10Prmt2-Pdxk)4Yey Location: Chr10:76043060-78300782 bp Genetic Position: Chr10, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:161398
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intergenic deletion, Intragenic deletion Del(10Prmt2-Pdxk)4Yey involves 85 genes/genome features (n-TAagc5, n-R5s77, Gm19376 ...) View all Mutation details: Cre mediated chromosomal rearrangement between loxP sites in regions proximal to Prmt2 and distal to Pdxk resulted in deletion of the genes, including Prmt2 and Pdxk, in this approximately 2.3 Mb region that is syntenic with the distal part of human 21q22.3. (J:161398)

Generation of the Del(10Prmt2-Pdxk)4Yey deletion

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Del(10Prmt2-Pdxk)4Yey Mutation: 1 strain or line available

References

• Original: J:161398 Yu T, et al., Deficiencies in the region syntenic to human 21q22.3 cause cognitive deficits in mice. Mamm Genome. 2010 Jun;21(5-6):258-67
• All: 1 reference(s)