Gja5^tm1Mchn
Targeted Allele Detail

Summary

• Symbol: Gja5^tm1Mchn
• Name: gap junction protein, alpha 5; targeted mutation 1, Marc Chanson
• MGI ID: MGI:4818408
• Synonyms: Cx40^fl, Gja5^flox
• Gene: Gja5 Location: Chr3:96939718-96960950 bp, + strand Genetic Position: Chr3, 42.04 cM
• Alliance: Gja5^tm1Mchn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:162224
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neo cassette was inserted upstream of exon 2, and a loxP site was inserted downstream of exon 2. The loxP-neomycin-loxP cassette was excised from the targeted ES cells by transient in vitro expression of cre recombinase, leaving exon 2 flanked by loxP sites. (J:162224)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gja5 Mutation: 19 strains or lines available

References

• Original: J:162224 Chadjichristos CE, et al., Endothelial-specific deletion of connexin40 promotes atherosclerosis by increasing CD73-dependent leukocyte adhesion. Circulation. 2010 Jan 5;121(1):123-31
• All: 6 reference(s)