Hoxc8^{tm2.1(cre)Mrc}
Targeted Allele Detail

Summary

• Symbol: Hoxc8^{tm2.1(cre)Mrc}
• Name: homeobox C8; targeted mutation 2.1, Mario R Capecchi
• MGI ID: MGI:4818428
• Synonyms: C8cre, Hoxc8-ICre
• Gene: Hoxc8 Location: Chr15:102899039-102902543 bp, + strand Genetic Position: Chr15, 58.05 cM
• Alliance: Hoxc8^{tm2.1(cre)Mrc} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:162102
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Hoxc8^{tm2.1(cre)Mrc} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Hoxc8 (MGI:96198)

• Mutation details: A fragment consisting of cre recombinase preceded by an internal ribosomal entry site (IRES) and followed by an FRT-neo-FRT cassette was inserted into the 3' UTR of exon 2 of Hoxc8. The neomycin cassette was subsequently removed by breeding with FLPe deleter animals. (J:162102)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Hoxc8 (mouse) Summary of all recombinase alleles driven by Hoxc8. Comparative matrix view of recombinase activities Alliance mouse Hoxc8 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxc8 Mutation: 8 strains or lines available

References

• Original: J:162102 Chen SK, et al., Hematopoietic origin of pathological grooming in Hoxb8 mutant mice. Cell. 2010 May 28;141(5):775-85
• All: 2 reference(s)