Hoxb8^{tm4.1(cre/Esr1*)Mrc}
Targeted Allele Detail

Summary

• Symbol: Hoxb8^{tm4.1(cre/Esr1*)Mrc}
• Name: homeobox B8; targeted mutation 4.1, Mario R Capecchi
• MGI ID: MGI:4818431
• Synonyms: Hoxb8-CreER^TM
• Gene: Hoxb8 Location: Chr11:96172731-96176141 bp, + strand Genetic Position: Chr11, 59.82 cM
• Alliance: Hoxb8^{tm4.1(cre/Esr1*)Mrc} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:162102
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutations: Insertion, Intragenic deletion
• Hoxb8^{tm4.1(cre/Esr1*)Mrc} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Hoxb8 (MGI:96189)

• Mutation details: Exon 1 of Hoxb8 was replaced with cre fused to a mutated estrogen receptor followed by an FRT-flanked neo selection cassette. The neo was subsequently removed by breeding to FLPe deleter animals. In homozygous mice, the allele acts as a null allele for Hoxb8. (J:162102)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Hoxb8 (mouse) Summary of all recombinase alleles driven by Hoxb8. Alliance mouse Hoxb8 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxb8 Mutation: 8 strains or lines available

References

• Original: J:162102 Chen SK, et al., Hematopoietic origin of pathological grooming in Hoxb8 mutant mice. Cell. 2010 May 28;141(5):775-85
• All: 1 reference(s)