Hoxb8^{tm3.1(IRES-rtTA2*M2)Mrc}
Targeted Allele Detail

Summary

• Symbol: Hoxb8^{tm3.1(IRES-rtTA2*M2)Mrc}
• Name: homeobox B8; targeted mutation 3.1, Mario R Capecchi
• MGI ID: MGI:4818439
• Synonyms: Hoxb8^c
• Gene: Hoxb8 Location: Chr11:96172731-96176141 bp, + strand Genetic Position: Chr11, 59.82 cM
• Alliance: Hoxb8^{tm3.1(IRES-rtTA2*M2)Mrc} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:162102
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Lox511 sites were inserted into the 5' and 3' UTRs of the Hoxb8 gene. An FRT-flanked neo selection cassette followed the 3' lox511 site. For temporal control of gene activation, an IRES-rtTA2M2 seqment was also introduced into the 3' UTR, along with an FRT-flanked neo selection cassette. The neo was subsequently removed by breeding with FLPe deleter animals. (J:162102)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxb8 Mutation: 8 strains or lines available

References

• Original: J:162102 Chen SK, et al., Hematopoietic origin of pathological grooming in Hoxb8 mutant mice. Cell. 2010 May 28;141(5):775-85
• All: 1 reference(s)