Hoxa1^{tm7.1(cre)Mrc}
Targeted Allele Detail

Summary

• Symbol: Hoxa1^{tm7.1(cre)Mrc}
• Name: homeobox A1; targeted mutation 7.1, Mario R Capecchi
• MGI ID: MGI:4818445
• Synonyms: Hoxa1^IC, Hoxa1-IRES-Cre
• Gene: Hoxa1 Location: Chr6:52132573-52135299 bp, - strand Genetic Position: Chr6, 25.4 cM
• Alliance: Hoxa1^{tm7.1(cre)Mrc} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:160496
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Hoxa1^{tm7.1(cre)Mrc} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Hoxa1 (MGI:96170)

• Mutation details: An IRES-cre-FRT-MC1-Neo-FRT cassette was inserted 36 bp downstream of the stop codon of the Hoxa1 gene by recombination in R1 ES cells. Chnmeras were crossed to FLPe deleter mice to remove the neo selection marker. (J:160496)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Hoxa1 (mouse) Summary of all recombinase alleles driven by Hoxa1. Alliance mouse Hoxa1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxa1 Mutation: 14 strains or lines available

References

• Original: J:160496 Makki N, et al., Hoxa1 lineage tracing indicates a direct role for Hoxa1 in the development of the inner ear, the heart, and the third rhombomere. Dev Biol. 2010 May 15;341(2):499-509
• All: 2 reference(s)