Sgms2^tm1Jia
Targeted Allele Detail

Summary

• Symbol: Sgms2^tm1Jia
• Name: sphingomyelin synthase 2; targeted mutation 1, Xian-Cheng Jiang
• MGI ID: MGI:4818459
• Synonyms: SMS2^-
• Gene: Sgms2 Location: Chr3:131112634-131197172 bp, - strand Genetic Position: Chr3, 60.91 cM
• Alliance: Sgms2^tm1Jia page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:162226
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: 90% of exon 2 was replaced with a neo cassette. The absence of transcript expression was confirmed by RT-PCR on macrophage extracts. (J:162226)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sgms2 Mutation: 24 strains or lines available

References

• Original: J:162226 Hailemariam TK, et al., Sphingomyelin synthase 2 deficiency attenuates NFkappaB activation. Arterioscler Thromb Vasc Biol. 2008 Aug;28(8):1519-26
• All: 16 reference(s)