Ttyh1^tm1Tohe
Targeted Allele Detail

Summary

• Symbol: Ttyh1^tm1Tohe
• Name: tweety family member 1; targeted mutation 1, Toshio Heike
• MGI ID: MGI:4818475
• Gene: Ttyh1 Location: Chr7:4122418-4139206 bp, + strand Genetic Position: Chr7, 2.38 cM, cytoband A1
• Alliance: Ttyh1^tm1Tohe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:161796
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Ttyh1^tm1Tohe involves 1 genes/genome features (D030047H15Rik) View all
• Mutation details: Exons 5 to 10 were replaced with a neo cassette via homologous recombination. Analyisis of genomic structure in J:291664 indicates that the gene accommodates a long non-coding RNA D030047H15Rik and that deletion of exons 5-10 would disrupt this lncRNA. (J:161796, J:291664)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ttyh1 Mutation: 44 strains or lines available

References

• Original: J:161796 Kumada T, et al., Ttyh1, a Ca(2+)-binding protein localized to the endoplasmic reticulum, is required for early embryonic development. Dev Dyn. 2010 Aug;239(8):2233-45
• All: 2 reference(s)