Cntnap1^tm1Bhat
Targeted Allele Detail

Summary

• Symbol: Cntnap1^tm1Bhat
• Name: contactin associated protein-like 1; targeted mutation 1, Manzoor A Bhat
• MGI ID: MGI:4818635
• Synonyms: CASPR-lacZ
• Gene: Cntnap1 Location: Chr11:101065429-101081550 bp, + strand Genetic Position: Chr11, 64.33 cM, cytoband D
• Alliance: Cntnap1^tm1Bhat page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:107653
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lacZ-neomycin construct was inserted in exon 17. Northern blot analysis indicated that no transcript was produced and Western blot analysis indicated the absence of protein product. (J:107653)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cntnap1 Mutation: 56 strains or lines available

References

• Original: J:107653 Garcia-Fresco GP, et al., Disruption of axo-glial junctions causes cytoskeletal disorganization and degeneration of Purkinje neuron axons. Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):5137-42
• All: 3 reference(s)