Slc26a4^tm1Sole
Targeted Allele Detail

Summary

• Symbol: Slc26a4^tm1Sole
• Name: solute carrier family 26, member 4; targeted mutation 1, Manoocher Soleimani
• MGI ID: MGI:4818636
• Gene: Slc26a4 Location: Chr12:31569826-31609968 bp, - strand Genetic Position: Chr12, 13.53 cM, cytoband B1
• Alliance: Slc26a4^tm1Sole page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:162257
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv * C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neo cassette replaced exons 1-3, including the ATG initiation site in exon 2. Absence of protein was confirmed by western blot. (J:162257)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Slc26a4^tm1Sole/Slc26a4^tm1Sole	involves: 129S/SvEv * C57BL/6

Phenotypes:

Affected Systems	hm1
show or hide all annotated terms
homeostasis/metabolism	√
increased urine ammonia level	√
increased circulating bicarbonate level	√
decreased urine pH	√
renal/urinary system	√
increased urine ammonia level	√
decreased urine pH	√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc26a4 Mutation: 40 strains or lines available

References

• Original: J:162257 Amlal H, et al., Deletion of the anion exchanger Slc26a4 (pendrin) decreases apical Cl(-)/HCO3(-) exchanger activity and impairs bicarbonate secretion in kidney collecting duct. Am J Physiol Cell Physiol. 2010 Jul;299(1):C33-41
• All: 9 reference(s)