Rbl1^tm2.1Jsag
Targeted Allele Detail

Summary

• Symbol: Rbl1^tm2.1Jsag
• Name: RB transcriptional corepressor like 1; targeted mutation 2.1, Julien Sage
• MGI ID: MGI:4818639
• Synonyms: p107E2F-2*
• Gene: Rbl1 Location: Chr2:156987813-157046454 bp, - strand Genetic Position: Chr2, 78.05 cM
• Alliance: Rbl1^tm2.1Jsag page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:161509
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

Allele Type: Targeted (Not Applicable) Mutation: Insertion Mutation details: A floxed neo resistance cassette was inserted within intron 1 on the BAC RP23-163J20. E2F binding site 2, TTTgtcGC, was mutated to TTTaaaGC. This BAC was then introduced by homologous recombination. The selection cassette was removed by cre mediated recombination. (J:161509)

Generation of the Rbl1^tm1.1Jsag, Rbl1^tm2.1Jsag, and Rbl1^tm3.1Jsag alleles

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rbl1 Mutation: 60 strains or lines available

References

• Original: J:161509 Burkhart DL, et al., Tandem E2F binding sites in the promoter of the p107 cell cycle regulator control p107 expression and its cellular functions. PLoS Genet. 2010;6(6):e1001003
• All: 1 reference(s)