Rbl1^tm3.1Jsag
Targeted Allele Detail

Summary

• Symbol: Rbl1^tm3.1Jsag
• Name: RB transcriptional corepressor like 1; targeted mutation 3.1, Julien Sage
• MGI ID: MGI:4818640
• Synonyms: p107E2F-1*2*
• Gene: Rbl1 Location: Chr2:156987813-157046454 bp, - strand Genetic Position: Chr2, 78.05 cM
• Alliance: Rbl1^tm3.1Jsag page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:161509
• Parent Cell Line: V26.2 (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

Allele Type: Targeted (Not Applicable) Mutation: Insertion Mutation details: A floxed neo resistance cassette was inserted within intron 1 on the BAC RP23-163J20. E2F binding site 1, TTTCgcgC, was mutated to TTTCaaaC and E2F binding site 2, TTTgtcGC, was mutated to TTTaaaGC. This BAC was then introduced by homologous recombination. The selection cassette was removed by cre mediated recombination. (J:161509)

Generation of the Rbl1^tm1.1Jsag, Rbl1^tm2.1Jsag, and Rbl1^tm3.1Jsag alleles

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rbl1 Mutation: 60 strains or lines available

References

• Original: J:161509 Burkhart DL, et al., Tandem E2F binding sites in the promoter of the p107 cell cycle regulator control p107 expression and its cellular functions. PLoS Genet. 2010;6(6):e1001003
• All: 1 reference(s)