Ucn3^tm1.1Jde
Targeted Allele Detail

Summary

• Symbol: Ucn3^tm1.1Jde
• Name: urocortin 3; targeted mutation 1.1, Jan Deussing
• MGI ID: MGI:4818652
• Synonyms: Ucn3^tZ
• Gene: Ucn3 Location: Chr13:3990688-3995349 bp, - strand Genetic Position: Chr13, 2.2 cM, cytoband A1
• Alliance: Ucn3^tm1.1Jde page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:161776
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 3.6 kb fragment including exon which encodes for the entire open reading frame was replaced with a tau-lacZ reporter and a self-excising neo cassette via homologous recombination. In situ hybridization confirmed the absence of transcript in brains from homozygous mice. X-gal staining confirmed that lacZ expression recapitulated endogenous gene expression. (J:161776)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ucn3 Mutation: 21 strains or lines available

References

• Original: J:161776 Deussing JM, et al., Urocortin 3 modulates social discrimination abilities via corticotropin-releasing hormone receptor type 2. J Neurosci. 2010 Jul 7;30(27):9103-16
• All: 3 reference(s)