Pparg^tm1.2Auw
Targeted Allele Detail

Summary

• Symbol: Pparg^tm1.2Auw
• Name: peroxisome proliferator activated receptor gamma; targeted mutation 1.2, Johan Auwerx
• MGI ID: MGI:4818655
• Synonyms: Pparg2^-
• Gene: Pparg Location: Chr6:115337912-115467360 bp, + strand Genetic Position: Chr6, 53.41 cM, cytoband E3-F1
• Alliance: Pparg^tm1.2Auw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:161746
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutations: Insertion, Intragenic deletion
• Mutation details: A hypomorphic allele Pparg^tm1Auwwas crossed successively with transgenic C57Bl/6J mice expressing FLP and Cre recombinases to remove the frt flanked neomycin selection cassette and the loxP flanked exon B specific for the Pparg2 isoform. Absence of Pparg2 isoform specific transcripts was confirmed by RTPCR. (J:161746)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pparg Mutation: 41 strains or lines available

References

• Original: J:161746 Argmann C, et al., Ppargamma2 is a key driver of longevity in the mouse. PLoS Genet. 2009 Dec;5(12):e1000752
• All: 1 reference(s)