Ffar4^tm1Sdmk
Targeted Allele Detail

Summary

• Symbol: Ffar4^tm1Sdmk
• Name: free fatty acid receptor 4; targeted mutation 1, Sami Damak
• MGI ID: MGI:4818767
• Synonyms: GPR120 KO
• Gene: Ffar4 Location: Chr19:38085527-38102711 bp, + strand Genetic Position: Chr19, 32.73 cM
• Alliance: Ffar4^tm1Sdmk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:161517
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment extending from nucleotide -5870 to 768 including the promoter region and exon 1 was replaced with a pgk-neo cassette via homologous recombination. Immunohistochemical analysis confirmed the absence of protein expression in taste tissue from homozygous mice. (J:161517)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ffar4 Mutation: 25 strains or lines available

References

• Original: J:161517 Cartoni C, et al., Taste preference for fatty acids is mediated by GPR40 and GPR120. J Neurosci. 2010 Jun 23;30(25):8376-82
• All: 4 reference(s)