Tg(ACTA1-rtTA,tetO-cre)102Monk
Transgene Detail

Summary

• Symbol: Tg(ACTA1-rtTA,tetO-cre)102Monk
• Name: transgene insertion 102, Douglas Monks
• MGI ID: MGI:4818775
• Synonyms: HSA-rtTA/TRE-Cre, TRE-Cre
• Transgene: Tg(ACTA1-rtTA,tetO-cre)102Monk Location: unknown
• Alliance: Tg(ACTA1-rtTA,tetO-cre)102Monk page

Transgene origin

• Strain of Origin: (C57BL/6 x C3H)F2

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase, Transactivator)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(ACTA1-rtTA,tetO-cre)102Monk expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  human

  ACTA1 (58)

  Acta1

  (MGI:87902)

• Mutation details: A transgenic construct containing cre recombinase under the control of the tetracycline-responsive regulatory element (tetO) and a second transgenic construct containing rtTA, under the control of the human ACTA1, actin, alpha 1, skeletal muscle promoter were coinjected into fertilized (C57BL/6 X C3H)F2 mouse eggs. Founder line 102 was subsequently established. Female founder animals were bred to wildtype C57BL/6J mice. (J:159973)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	ACTA1 (human) Summary of all recombinase alleles driven by ACTA1. Comparative matrix view of recombinase activities Alliance human ACTA1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:159973 Rao P, et al., A tetracycline-inducible and skeletal muscle-specific Cre recombinase transgenic mouse. Dev Neurobiol. 2009 May;69(6):401-6
• All: 37 reference(s)