As3mt^tm1Djth
Targeted Allele Detail

Summary

• Symbol: As3mt^tm1Djth
• Name: arsenite methyltransferase; targeted mutation 1, David Thomas
• MGI ID: MGI:4818883
• Gene: As3mt Location: Chr19:46695897-46729538 bp, + strand Genetic Position: Chr19, 38.97 cM, cytoband D1
• Alliance: As3mt^tm1Djth page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:162148
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neo gene replaced exons 3 and 4 and possibly part of 5 by homologous recombination. The knock-out was confirmed by western blotting of liver lysates. (J:162148)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any As3mt Mutation: 23 strains or lines available

References

• Original: J:162148 Drobna Z, et al., Disruption of the arsenic (+3 oxidation state) methyltransferase gene in the mouse alters the phenotype for methylation of arsenic and affects distribution and retention of orally administered arsenate. Chem Res Toxicol. 2009 Oct;22(10):1713-20
• All: 6 reference(s)