Itga5^tm2Hyn
Targeted Allele Detail

Summary

• Symbol: Itga5^tm2Hyn
• Name: integrin alpha 5 (fibronectin receptor alpha); targeted mutation 2, Richard Hynes
• MGI ID: MGI:4818931
• Synonyms: alpha5^flox
• Gene: Itga5 Location: Chr15:103252713-103275190 bp, - strand Genetic Position: Chr15, 58.9 cM
• Alliance: Itga5^tm2Hyn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:161850
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked neo cassette was inserted 5' to a loxP flanked exon 1 by homologous recombination. The selection cassette was removed by flp-mediated recombination. (J:159465, J:161850)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Itga5 Mutation: 47 strains or lines available

References

• Original: J:161850 van der Flier A, et al., Endothelial alpha5 and alphav integrins cooperate in remodeling of the vasculature during development. Development. 2010 Jul;137(14):2439-49
• All: 21 reference(s)