Itga5^tm2.1Hyn
Targeted Allele Detail

Summary

• Symbol: Itga5^tm2.1Hyn
• Name: integrin alpha 5 (fibronectin receptor alpha); targeted mutation 2.1, Richard Hynes
• MGI ID: MGI:4818933
• Gene: Itga5 Location: Chr15:103252713-103275190 bp, - strand Genetic Position: Chr15, 58.9 cM
• Alliance: Itga5^tm2.1Hyn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:161850
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A FRT-flanked Neo cassette and exon 1 were floxed by homologous recombination. The Neo cassette and exon 1 were removed by flp- and cre- mediate recombination respectively. (J:161850)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Itga5 Mutation: 47 strains or lines available

References

• Original: J:161850 van der Flier A, et al., Endothelial alpha5 and alphav integrins cooperate in remodeling of the vasculature during development. Development. 2010 Jul;137(14):2439-49
• All: 1 reference(s)