Tg(Prnp-APP*)1Hmor
Transgene Detail

Summary

• Symbol: Tg(Prnp-APP*)1Hmor
• Name: transgene insertion 1, Hiroshi Mori
• MGI ID: MGI:4818971
• Synonyms: APP^E693delta
• Transgene: Tg(Prnp-APP*)1Hmor Location: unknown
• Alliance: Tg(Prnp-APP*)1Hmor page

Transgene origin

• Strain of Origin: (C57BL/6N x C3H/HeN)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Prnp-APP*)1Hmor expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  APP (351)

  App	(MGI:88059)

• Mutation details: The mouse promoter drives expression of the human cDNA with nucleotide deletions that result in the deletion of aspartic acid at position 693 (E693delta). Three lines were generated (lines 1, 2, and 3) with high, low, and intermediate expression levels, respectively. (J:123688)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:123688 Matsuyama S, et al., Inverse correlation between amyloid precursor protein and synaptic plasticity in transgenic mice. Neuroreport. 2007 Jul 2;18(10):1083-7
• All: 4 reference(s)