Tg(Emu-FGFR3)A5Wmk
Transgene Detail

Summary

• Symbol: Tg(Emu-FGFR3)A5Wmk
• Name: transgene insertion A5, W Michael Kuehl
• MGI ID: MGI:4818998
• Transgene: Tg(Emu-FGFR3)A5Wmk Location: unknown
• Alliance: Tg(Emu-FGFR3)A5Wmk page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Emu-FGFR3)A5Wmk expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  FGFR3 (2261)

  Fgfr3

  (MGI:95524)

• Mutation details: The Emu enchancer and Lck proximal promoter drive B and T cell-specific expression of the human cDNA (FGFR3 IIIc isoform). Six founder mice (founders H1, D3, A5, and K1) were generated. (J:160845)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:160845 Zingone A, et al., Ectopic expression of wild-type FGFR3 cooperates with MYC to accelerate development of B-cell lineage neoplasms. Leukemia. 2010 Jun;24(6):1171-8
• All: 1 reference(s)